名稱：毛細(xì)管柱

固定相：5%苯基-95%二甲基聚硅氧烷

規(guī)格：30m*0.32mm*0.5um

型號(hào)：HH-5

丙二酸二甲酯(DMM)是一種重要的醫(yī)藥中間體,廣泛應(yīng)用于各類有機(jī)合成反應(yīng)。目前工業(yè)上通用的DMM生產(chǎn)方法主要有氰化法和羰基化法兩大類,但這兩類方法都存在各自難以克服的問題：氰化法收率較低,且生產(chǎn)中使用劇毒的氰化鈉,易造成環(huán)境污染和人身傷害；羰基化法生產(chǎn)過程需要用到銠、鈀等貴金屬催化劑,增加了成本,且反應(yīng)條件較苛刻,危險(xiǎn)性較大。

浩瀚色譜（山東）應(yīng)用技術(shù)開發(fā)有限公司，研發(fā)氣相色譜法測定工業(yè)丙二酸二甲酯，HH-5毛細(xì)管柱測定，面積歸一法定量，結(jié)果滿意。

工業(yè)丙二酸二甲酯測定毛細(xì)管柱  測試譜圖：



Determination of dimethyl malonate for industrial use Capillary column

Details of capillary column for determination of dimethyl malonate for industrial use:



Name: capillary column



Stationary phase: 5% phenyl-95% dimethyl polysiloxane



Specification: 30m * 0.32mm * 0.5um



Model: HH-5



Dimethyl malonate (DMM) is an important pharmaceutical intermediate, which is widely used in various organic synthesis reactions. At present, DMM production methods commonly used in industry mainly include cyanidation method and carbonylation method, but these two methods have their own problems that are difficult to overcome: cyanidation method has low yield, and the use of highly toxic sodium cyanide in production is easy to cause environmental pollution and personal injury; The carbonylation process requires the use of noble metal catalysts such as rhodium and palladium, which increases the cost, and the reaction conditions are harsh and dangerous.



Haohan Chromatography (Shandong) Application Technology Development Co., Ltd. has developed a gas chromatography method for the determination of industrial dimethyl malonate, a HH-5 capillary column method for the determination, and an area normalization method for the quantification. The results are satisfactory.



Capillary column test spectrogram for determination of industrial dimethyl malonate: